Different clinical presentation of Anisakis simplex associated urticaria is dependent on the frequency of raw fish intake.

from Lolium perenne, Olea europaea, Artemisia vulgaris, Parietaria judaica and Platanus acerifolia.(Figure 1). Oral challenge test with raw cardoon produced pruritus in mouth and lips swelling 30 min after the ingestion whereas oral challenge with cooked cardoon did not produce any kind of symptomatology. We report a case of cardoon allergy confirmed by positive results in in vivo and in vitro tests. Our patient had personal antecedents of rhinoconjunctivitis and asthma due to inhalation of various pollens: Lolium perenne, Olea europaea, Artemisia vulgaris, Parietaria judaica and Platanus acerifolia. The symptomatology due to cardoon ingestion had taken place several years after the pollen allergy status began. We demostrated the existence of serologic crossreactivity among proteins from cardoon and some others from the pollens against which the patient was sensitised.